Councils are being urged to bid for a share of £4.8bn as part of the Government's Levelling Up Fund.
Applications for funding to implement projects that improve everyday life for people across the UK will be open until midday on 2 August 2022.
The first round of funding saw £1.7bn awarded to 105 successful projects.
In this round of funding, MPs will be allowed to support two bids rather than a single one, as their constituencies cover more than one council area.
Greg Clark, secretary of state for levelling up, housing and communities, said: 'The Levelling Up Fund can provide the investment needed to make a project that communities have been dreaming of for years a reality.
'So I’m delighted to open applications for the second round of the Levelling Up Fund and I’m looking forward to seeing proposals that will make a positive impact on people’s lives.'
